This study examined work-family interference experienced by working parents in a sample of 1888 employed adults. Role strain was examined using a multidimensional model that included family-related and work-related demands and resources. Multiple regression analyses revealed that having children under the age of six, more demanding jobs, less satisfactory child care arrangements, and less workplace support contributed significantly to higher levels of role strain. Utilization of workplace programs and benefits such as Dependent Care Accounts, Child Care Resource Guides, Parent Information Fairs, and adjusted work schedules did not significantly impact levels of work-family interference. Moreover, work and family resources were not found to have greater benefit for employees with more demanding work and family situations than for those with less demanding situations. These findings demonstrate the limited buffering ability of certain workplace and family resources, and the importance of identifying work-site as well as community-based programs and policies that have the greatest potential to assist working parents and their children. // (2001)